@8606bdb4 what happened at Penn is chronic in academia as is funder bias. Regarding this manuscript being rejected by Nature & Science and accepted by Immunology, it’s a reasonable outcome. Modified NA bases by 2005 weren’t novel and their impact on inflammation response to mRNA is more specialized than general interest. Hindsight is 20/20 after all.

External leadership is needed to realize genuine systemic reform. But, if SOS behavior in mCDR is any indication, it’s not happening anytime soon. 

 @8606bdb4 sounds good, but it would be better if there is at least one incumbent Bay Area group involved, besides the for-profit startup that is located in SF. The Bay, its history, and sheer number of jurisdictions with outflows make this an incredibly complex system. Please consider multiple site discharges based on a variety of CDR approaches as you design your studies. 

 @8606bdb4 are you looking for alternatives to Sigma-Aldrich?

https://www.sigmaaldrich.com/US/en/product/supelco/10478u 

 @8606bdb4 @77ee1552 another reason worm and more broadly macrobenthic organism restoration is needed.