Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks
https://www.biorxiv.org/content/10.1101/2023.10.04.560881v1
The genetic structure in Europe was mostly shaped by admixture between the Western Hunter-Gatherer
...
Heart rate, platelet count, monocyte percentage and many other traits show stratification similar to height and pigmentation traits, likely targets of selection and divergence across ancestral groups.
...
#genomics #GWAS #biobank #bioinformatics #genetics
A3 cont'd
Montana Judge Ruled State Constitution Bans New Fossil Fuel Plants
Young residents won a lawsuit charging that construction of new gas power plant barred by state constitution
But “pro-climate” President Joe Biden arguing fiercely against letting SCOTUS hear similar case
https://jacobin.com/2023/09/held-v-montana-court-constitutional-right-climate-change-youth-generations-environment
#Democrats #GOP #GOPmenace #Montana #SCOTUS #ClimateChange #ClimateCatastrophe #DoJ #FossilFuels #Biden #corporations #DefundCorporations #neoliberalism #StructuralViolence
Life-changing cystic fibrosis treatment wins US$3-million Breakthrough Prize
https://www.nature.com/articles/d41586-023-02890-1
Discussion: https://news.ycombinator.com/item?id=37535537
* triple-drug combination Trikafta helps 90% of people w. cystic fibrosis
* inherited disorder affecting lungs, other organs
* mutations in gene that makes the cystic fibrosis transmembrane conductance regulator protein (CFTR)
* involved in production of mucus, sweat, other fluids
#CysticFibrosis #Trikafta #disease #medicine #BreakthroughPrize #CFTR
A4 cont'd
* most notably nominating 3 conservative SCOTUS justices who helped overturn Roe v Wade 2022-06
* Trump also warned Republican extremism on abortion was losing them elections
* criticized Republican politicians for extreme anti-abortion rhetoric
* if they don’t speak about it correctly, they’re not going to win
* explaining it "properly" is extremely important
...
A4 cont'd 2/
* Trump’s primary rivals have taken that message to heart
* DeSantis, who spoke before Trump PVS, didn’t even mention aborrtion even though 2023-04 he signed into law a 6-week state abortion ban that should have been a FRCapplause line
* Ramaswamy also neglected to mention the topic despite being on record as supporting six6week state bans that would treat abortion like “murder.”
A4 cont'd
* most notably nominating 3 conservative SCOTUS justices who helped overturn Roe v Wade 2022-06
* Trump also warned Republican extremism on abortion was losing them elections
* criticized Republican politicians for extreme anti-abortion rhetoric
* if they don’t speak about it correctly, they’re not going to win
* explaining it "properly" is extremely important
...
cont'd 2/
PPN funded the anti-addition, anti-homeless "Vancouver Is Dying" propaganda - used to elect a political neophyte mayor of Vancouver; used by TBA in recent Alberta election.
Back to Lonsdale: model acts (carbon copy legislation distributed to U.S. legislatures to enact neoconservative agendae) are a bane of U.S. politics.
Like ALEC/others, the Cicero Institute churns out model acts including this gem:
Reducing Street Homelessness Act
https://invisiblepeople.tv/private-prisons-for-homeless-criminalizationhttps://persagen.com/docs/cicero_institute.html
cont'd
That solution includes the demonization of homelessness and the involuntary (for-profit) incarceration and treatment.
Billionaires profiting from human misery; poverty industrial complex.
Vancouver, B.C. Canada billionaire (who behind the scenes funds elections of far-right political candidates here and Alberta - e.g. Take Back Alberta far-right group) has the Pacific Prosperity Network.
...
cont'd 2/
PPN funded the anti-addition, anti-homeless "Vancouver Is Dying" propaganda - used to elect a political neophyte mayor of Vancouver; used by TBA in recent Alberta election.
Back to Lonsdale: model acts (carbon copy legislation distributed to U.S. legislatures to enact neoconservative agendae) are a bane of U.S. politics.
Like ALEC/others, the Cicero Institute churns out model acts including this gem:
Reducing Street Homelessness Act
https://invisiblepeople.tv/private-prisons-for-homeless-criminalizationhttps://persagen.com/docs/cicero_institute.html
Addendum 6
Perusing my morning informational feeds and this parasite popped up via the Hacker News post (I script the most upvoted &/or commented to be emailed to me, daily).
An article by billionaire neofascist Joe Lonsdale, https://blog.joelonsdale.com/p/jefferson-and-americas-lost-idea, espousing his twisted ideology. The HN discussion, https://news.ycombinator.com/item?id=37532234, thus far fails to correctly identify Lonsdale for who he is, the danger he presents.
Lonsdale's Cicero Institute cloaks itself as a solution to the issue of homelessness.
cont'd
That solution includes the demonization of homelessness and the involuntary (for-profit) incarceration and treatment.
Billionaires profiting from human misery; poverty industrial complex.
Vancouver, B.C. Canada billionaire (who behind the scenes funds elections of far-right political candidates here and Alberta - e.g. Take Back Alberta far-right group) has the Pacific Prosperity Network.
...
A1 cont'd 2/
They all self-identify as "libertarian," cloaking their neoliberal ideology espoused in this addendum.
Moreover - regarding the U.S. / increasingly Canada - I equate "neoliberalism" with the neofascism agendae / policies of the Republican Party.
#economics #SCOTUS #neoliberalism #neofascism #GOP #GOPmenace #capitalism #corporations #DefundCorporations #PrivateEquity #DefundBillionaires #democracy #socialism #liberalism #CharlesKoch
A1 cont'd
I adopt the pejorative use of the term "neoliberalism" when discussing Western governments / economies - particularly the U.S., Canada, U.K. ...
For the U.S. particularly I associate "neoliberalism" with the drive by organizations (World Economic Forum; Cato Institute ...), persons (Charles Koch) to defund government, reduce government regulation, advocate legal personship (e.g. freedom of speech applied to corporations: McConnell / SCOTUS / Citizens United / ...).
...
A1 cont'd 2/
They all self-identify as "libertarian," cloaking their neoliberal ideology espoused in this addendum.
Moreover - regarding the U.S. / increasingly Canada - I equate "neoliberalism" with the neofascism agendae / policies of the Republican Party.
#economics #SCOTUS #neoliberalism #neofascism #GOP #GOPmenace #capitalism #corporations #DefundCorporations #PrivateEquity #DefundBillionaires #democracy #socialism #liberalism #CharlesKoch
A1 cont'd
I adopt the pejorative use of the term "neoliberalism" when discussing Western governments / economies - particularly the U.S., Canada, U.K. ...
For the U.S. particularly I associate "neoliberalism" with the drive by organizations (World Economic Forum; Cato Institute ...), persons (Charles Koch) to defund government, reduce government regulation, advocate legal personship (e.g. freedom of speech applied to corporations: McConnell / SCOTUS / Citizens United / ...).
...
[thread] Liberalism, neoliberalism
Liberalism: https://en.wikipedia.org/wiki/Liberalism
* political/moral philosophy
* based on rights of individual, liberty, consent of governed, political equality, right to private property, equality before law
Neoliberalism: https://en.wikipedia.org/wiki/Neoliberalism
* modern reinterpretation of 19th-century liberalism
* assoc. w. free-market capitalism
* gave rise to conservative & right-libertarian organizations, political parties, think tanks
#history #economics #liberalism #neoliberalism
Addendum 13
Large Language Model for Science: P vs. NP
https://arxiv.org/abs/2309.05689
* LLM to augment/accel. research on P vs. NP problem: https://en.wikipedia.org/wiki/P_versus_NP_problem
+ unsolved prob., theor. comp. sci.
+ asks wh. every problems quickly verified can also be quickly solved
* in-depth thinking w. LLM for complex problem-solving
* GPT-4 produced proof schema, engaged in rigorous reasoning throughout 97 dialogue turns (Socratic method)
* concluded P ≠ NP in alignment w. Xu & Zhou 2023
#LLM #GPT4 #PvsNP
A2 cont'd
Oregon County Sues BP, Chevron, Shell, Exxon for $51B Climate Damages
https://mastodon.social/@persagen/110645499062622887
Multnomah County, which includes Portland, sued 17 companies, including Shell, Exxon Mobil, Chevron, BP ... blaming them and seeking $51 billion in damages for the deadly 2021 Pacific Northwest heat wave that killed about 800 people.
Addendum 2
California Sues Giant Oil Companies, Citing Decades of Deception
https://www.nytimes.com/2023/09/15/business/california-oil-lawsuit-newsom.html
* claims Exxon, Chevron, Shell, BP, ConocoPhillips, American Petroleum Institute misled public
* downplayed risks of fossil fuels
* actions caused tens of billions of dollars damage
* seeks special fund to pay for recovery
#Exxon #ExxonMobil #ShellPlc #BP #Chevron # ConocoPhillips #AmericanPetroleumInstitute #GlobalWarming #DefundCorporations #FossilFuels #ClimateChangeDenial #FossilFuelsLobby
A2 cont'd
Oregon County Sues BP, Chevron, Shell, Exxon for $51B Climate Damages
https://mastodon.social/@persagen/110645499062622887
Multnomah County, which includes Portland, sued 17 companies, including Shell, Exxon Mobil, Chevron, BP ... blaming them and seeking $51 billion in damages for the deadly 2021 Pacific Northwest heat wave that killed about 800 people.
Addendum 17
Saskatchewan Child Advocate: Pronoun policy could run contrary to human rights laws, needs changes
https://regina.ctvnews.ca/sask-child-advocate-pronoun-policy-could-run-contrary-to-human-rights-laws-needs-changes-1.6563883
* Sask. Child Advocate says prov. gov.'s new policy regarding use of different pronouns in schools could violate human rights
* policy req. students <16 y.o. to seek parental consent before changing pronouns or preferred first names
#Canada #populism #Saskatchewan #ScottMoe #FarRight #education #transphobia #Action4Canada #SOGI #ChristianRight #HumanRights
A3 cont'd
* FRC plans to turn out conservative Christian voters. elect right-wing candidates in swing states
* FRC board chair, fmr. Rep. Michele Bachmann (R-MN; https://en.wikipedia.org/wiki/Michele_Bachmann) pitched for contributions
* warned 2024 election “might be last chance” to save the U.S. 🤨
https://persagen.com >> search: "Jody Hice"
"family research council"
"frc action"
"family research council" AND "leonard leo"
https://www.rightwingwatch.org/people/jody-hice
#FamilyResearchCouncil #FRCAction #ChristianRight #theocracy
A6 cont'd 3/
UAW Members Are Striking Against Corporate Power. Americans Overwhelmingly Back Them
https://jacobin.com/2023/09/uaw-members-strike-corporate-power-union-public-opinion-backing-autoworkers
* United Auto Workers president Shawn Fain said “We fight for the good of the entire working class”
* Americans believe him. In massive numbers, they tell pollsters they back UAW over Big Three auto companies
#UAW #TradeUnions #capitalism #corporations #CorporateGreed #DefundCorporations #DefundBillionaires #ShawnFein
A6 cont'd 4
UAW President Shawn Fain: “It Is Long Past Time to Stand Up for the Working Class”
https://jacobin.com/2023/09/shawn-fain-speech-uaw-stand-up-strike-working-class-unions-uaw/
* speech to United Auto Workers members, Shawn Fain laid into the Big Three
* explained the UAW's new “stand-up strike"
* [Oy! 🤨 ] invoked Bible to declare their battle a righteous fight for justice 🤦♀️
#UAW #TradeUnions #capitalism #corporations #CorporateGreed #DefundCorporations #DefundBillionaires #ShawnFein #populism
A1 cont'd 4/
This post meandered a bit from my original objection viz-a-viz the CBC, but it hopefully provides additional context (at least from my point-of-view).
There are historic and topical concerns in the use of language; choice of words matters.
#CBC #MeghanMuphy #TERF #JordanPeterson #trolls #pseudointellectualism #transphobia #FreeSpeech #CultureWars #WedgeTactics #WedgeStrategy #FarRight #ConspiracyTheories
A1 cont'd 5/
Postscript. Another issue that I have with the term "grooming" is an implicit understanding that the victim (gen. a juvenile) is compliant i.e. a willing participant. They are victims - mentally, psychologically, emotionally, financially - who are preyed upon by those with power and influence. There is a majority/minority inequality that the pedophile / sexual predator / child abuser uses to their advantage, with no concern for their victim. Psychological control of the victim.
Addendum 17
Saskatchewan Child Advocate: Pronoun policy could run contrary to human rights laws, needs changes
https://regina.ctvnews.ca/sask-child-advocate-pronoun-policy-could-run-contrary-to-human-rights-laws-needs-changes-1.6563883
* Sask. Child Advocate says prov. gov.'s new policy regarding use of different pronouns in schools could violate human rights
* policy req. students <16 y.o. to seek parental consent before changing pronouns or preferred first names
#Canada #populism #Saskatchewan #ScottMoe #FarRight #education #transphobia #Action4Canada #SOGI #ChristianRight #HumanRights
Addendum 2
California Sues Giant Oil Companies, Citing Decades of Deception
https://www.nytimes.com/2023/09/15/business/california-oil-lawsuit-newsom.html
* claims Exxon, Chevron, Shell, BP, ConocoPhillips, American Petroleum Institute misled public
* downplayed risks of fossil fuels
* actions caused tens of billions of dollars damage
* seeks special fund to pay for recovery
#Exxon #ExxonMobil #ShellPlc #BP #Chevron # ConocoPhillips #AmericanPetroleumInstitute #GlobalWarming #DefundCorporations #FossilFuels #ClimateChangeDenial #FossilFuelsLobby
A5 cont'd
No Accident Poverty Just Jumped
Spiked after lawmakers let antipoverty programs expire
https://inequality.org/research/poverty-spike
* 60% incr. 2021-2022 b/c politicians allowed proven income support programs to expire
* frising prices, low wages, high rents, broken healthcare system
* w/o safety net/level playing field, financial security often out of reach for families
Income, Poverty & Health Insurance Statistics: https://www.census.gov/newsroom/press-kits/2023/income-poverty.html
#GOP #GOPmenace #poverty #ChildPoverty #HumanRights #inflation
Addendum 6
Perusing my morning informational feeds and this parasite popped up via the Hacker News post (I script the most upvoted &/or commented to be emailed to me, daily).
An article by billionaire neofascist Joe Lonsdale, https://blog.joelonsdale.com/p/jefferson-and-americas-lost-idea, espousing his twisted ideology. The HN discussion, https://news.ycombinator.com/item?id=37532234, thus far fails to correctly identify Lonsdale for who he is, the danger he presents.
Lonsdale's Cicero Institute cloaks itself as a solution to the issue of homelessness.
A9 cont'd 2/
No One Man Should Have All That Power
As “free speech absolutist” Elon Musk continues his campaign of censorship at Twitter, we’re getting an exhibition in the outsized power of billionaires to shape our politics
https://jacobin.com/2023/09/twitter-elon-musk-free-speech-media-ukraine-starlink/
`
#Musk #oligarchy #WarInUkraine
Addendum 9
Waiving GST just a start. 3 ideas to get more housing built in Canada
Governments need to step up: experts
https://www.cbc.ca/news/business/armstrong-housing-crisis-build-1.6968475
* federal gov. decision to eliminate GST on purpose-built rentals expected to add tens of thousands of units to housing market: https://www.cbc.ca/news/politics/liberals-gst-rental-apartments-1.6966608
* just 1st step needed if Canada wants to close housing gap
* speed up approvals process
* more construction workers needed
* lower interest rates for financing
#AffordableHousing #Canada #housing
A4 cont'd 3/
* admins of official “One Million March For Freedom” Facebook group linked to “Hands Off Our Children”
* lists group of socially conservative Muslim activists & contributor to American right-wing website as spokespersons
* Kamel El-Cheikh, Dr. Bahira Abdulsalam, Mahmoud Mourra, David Krayden
#Canada #1MillionMarch4Children #transphobia #FarRight #ChristianRight #CultureWars #KamelElCheikh
Addendum 13
Large Language Model for Science: P vs. NP
https://arxiv.org/abs/2309.05689
* LLM to augment/accel. research on P vs. NP problem: https://en.wikipedia.org/wiki/P_versus_NP_problem
+ unsolved prob., theor. comp. sci.
+ asks wh. every problems quickly verified can also be quickly solved
* in-depth thinking w. LLM for complex problem-solving
* GPT-4 produced proof schema, engaged in rigorous reasoning throughout 97 dialogue turns (Socratic method)
* concluded P ≠ NP in alignment w. Xu & Zhou 2023
#LLM #GPT4 #PvsNP
A4 cont'd
* many organizers, groups behind marches have well-documented track records opposing 2SLGBTQIA+ rights, protesting vaccines & public health order, or subscribing to wide range of far-right conspiratorial narratives
* 1MillionMarch4Children emerged following rally led by Christian Nationalist youth group & an anti-trans activist targeting 3 Ottawa-area schools 2023-06
#Canada #1MillionMarch4Children #transphobia #FarRight #ChristianRight #CultureWars
A3 cont'd
Montana Judge Ruled State Constitution Bans New Fossil Fuel Plants
Young residents won a lawsuit charging that construction of new gas power plant barred by state constitution
But “pro-climate” President Joe Biden arguing fiercely against letting SCOTUS hear similar case
https://jacobin.com/2023/09/held-v-montana-court-constitutional-right-climate-change-youth-generations-environment
#Democrats #GOP #GOPmenace #Montana #SCOTUS #ClimateChange #ClimateCatastrophe #DoJ #FossilFuels #Biden #corporations #DefundCorporations #neoliberalism #StructuralViolence
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