Hi, Mike, writing from Gossip here :) My way of giving back for the benefits of your work is to share something about my personal journey in this regard. Short-term changes (diets) generally don't work. Lifestyle changes do. In my specific case, cutting out gluten + intermittent fasting (16:8) (with paleo) were crucial (I've been doing this for many, many years). It was a truly transformative experience. In my view (i am not a doctor), Medicine is a very, very complicated field. It's unavoidable (and can be beneficial, for sure) in extreme situations (when the benefits outweigh the risks), problematic in so many other cases. Our science tends to leak water when dealing with complexity (human body...). Listening to our own body and learning from the history of human evolution tend to yield better results in prevention. The results for me appeared within the first few weeks of experimenting with paleo (and the consequent elimination of gluten). Some other simple lifestyle changes with a high impact in my personal life include HIIT and proper breathing. But this is just my perception of the problem; I don't know if it's generalizable, although I have seen similar results in many people. 

 One detail: all these measures are simple (although they require discipline and persistence), and they all have a systemic impact. 

 Thanks. Yes we are complicated and all somewhat different. I experiment on myself a lot and I take a lot of clues from evolution, some evolutionary arguments are very convincing. Gluten alone didn't make much difference in my case, but cutting out coffee+milk+wheat for 2 weeks did fix my IBS for a while (until I started cheating)... it took almost 2 weeks for the result to occur which is probably why it has been so hard in the past to test foods (I didn't know I had to wait so long). HIIT is great. I climb hills as fast as I can, forcing myself to over-breathe makes it easier. My current keto diet is not a short-term change, it is a short-term experiment. I will evaluate what to take from it after I'm done experimenting.