Hi, Mike, writing from Gossip here :) My way of giving back for the benefits of your work is to share something about my personal journey in this regard. Short-term changes (diets) generally don't work. Lifestyle changes do. In my specific case, cutting out gluten + intermittent fasting (16:8) (with paleo) were crucial (I've been doing this for many, many years). It was a truly transformative experience. In my view (i am not a doctor), Medicine is a very, very complicated field. It's unavoidable (and can be beneficial, for sure) in extreme situations (when the benefits outweigh the risks), problematic in so many other cases. Our science tends to leak water when dealing with complexity (human body...). Listening to our own body and learning from the history of human evolution tend to yield better results in prevention. The results for me appeared within the first few weeks of experimenting with paleo (and the consequent elimination of gluten). Some other simple lifestyle changes with a high impact in my personal life include HIIT and proper breathing. But this is just my perception of the problem; I don't know if it's generalizable, although I have seen similar results in many people.