It really shines in group messaging for me. We moved our Bitcoin meetup chat to a group on there and it makes it very easy to manage. That's the biggest thing that isn't possible yet in Amethyst that I regularly use. It's the perfect replacement for Telegram/Matrix/Discord groups. 

Plus they're one of the only apps to support NIP-100 audio rooms. If nostrnests ever updates to NIP-100 you'd be able to join rooms straight from your 0xchat.