I'm not sure other clients even offer that configuration per use-case 

 It's probably safe to say Amethyst is the goat. 

 Oh, thanks, I was just about to ask how the general list worked with that. 

How does the 3-relay limit affect discovery? For example, a new nostrich comes in with wine, lol, and mom as relays. How well will their notes get out when they have no followers? I would say commenting to notes is the best way to be heard, but is that still an accurate statement? 

 Yes, if you comment or react to a note, you will post to the inbox relays of the note author and anyone in the tags. Then their clients will pull your notes from your outbox relays if they look at your profile or follow you