There are options on both sides.

Clients could provide better NIP05 filtering, let me mute replies from accounts without a NIP05 and let me blocklist keypairs with NIP05s from certain domains.

Paid relays already solve this but getting Users to adjust to them is a bigger ask. We’ve seen them work for 18+ months now but not everyone is willing to stump up money and put their attention behind a paywall. 

 I think reply guy is increasing the incentives for using paid & private relays.

That incentive will only increase in time.