I run #QubesOS on my desktop and #Proxmox on my servers. If you are only going to have one, I would go with Qubes. Proxmox doesn't come with a GUI and is really meant to be interacted with from another computer. Meanwhile, Qubes makes securely shuffling data around between VMs much easier.

On the flip side, if you can have both, Proxmox has easier comfiguration for getting traffic from the internet into the VM. This can be done in Qubes as well, but they kinda designed the system to prevent the internet from being able to directly get to a VM (other than the sys-net qube).

Hope this helps. 

 Thanks for the infos. Proxmox is basically debian, I mean, installing KDE or so shouldn't be a problem. Next weekend I'll try at first the proxmox setup, especially interested in performance of the VMs, when using in browser of the same host. And  most probably, it will not be satisfying for a desktop computer setup, so can install qubesos.
Last time I tried QubesOS, several years ago, I was basically using one vm 99% of the time. Do you use the proposed vms? I suppose networking setup doesn't require a rocket science degree... 

 
So lets try #Proxmox on a freshly installed #debian 12 with #KDE.

https://image.nostr.build/60c22673845ea3810d7f7f4609f85c160370dfe056c6e44e3dd9e46a5e050ee7.jpg

nostr:nevent1qqs2snyv52t4555snyl8j7lla6cm4cpguz94d7x4282st6tf6hgd4jqpp4mhxue69uhkummn9ekx7mqzypjyyxslk77pljfx80dwj36yl38nm9r5smk2ywkf3adgmkqyja7muqcyqqqqqqgdypdn8 

 Status update:

- after first install of #proxmox on a #debian 12 with #kde, had to reinstall it 3 times. At the end w/o kde. Well, 3 monitors and a graphic card are idle... will try to install kde on top and hope not to blow it up again.

- testing vms... debian with @umbrel and just Bitcoin Node and Nostr Relay for backup... GREAT!!! such easy setup (could have save me days of config)

- proxmox setup is quite easy... hardening will be slightly harder 😅


https://image.nostr.build/028dab0a307d89d99b7b267820bb310548fafdf53e5c9a18cb21cb2dde9c948c.jpg 

 many thanks to @scsibug 

 I blew it up... no time to fix. Back to pure #debian. (next week, I'll try #qubesos) 

 It’s been years since I tested Proxmoxx, but then again I got started with  virtualization when WMVare released their free beta in 99 or so :-)

Using QubesOS to fight this total war with powers that should never have been daily, so happy to find fellow users & of course even better if I can help out with anything!