Vaccination prevents loss of brain hippocampus neurogenesis, loss of memory, accumulation of IL-1β, #LongCovid central nervous system hit in the mouse model
https://nature.com/articles/s41590-024-01868-z 

 An update on protection of Covid vaccination against death and the political partisan gap on US Death tolls (←curves are still diverging)

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 The Nobel Prize in Medicine this week was not for Covid vaccines. It was about the messenger RNA platform discovery that “fundamentally changed our understanding of how mRNA interacts with the immune system.”

Reviewed in a new Ground Truths

https://erictopol.substack.com/p/a-nobel-prize-and-the-future-of-vaccines

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 The heightened and substantial risk of autoimmune diseases following Covid from the South Korea experience of >350,000 people with Covid and >6.1 million controls
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2810259

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 Now we're talking!
A trivalent nasal vaccine vs mumps, measles and Covid, broadly effective vs SARS-CoV-2 variants, with expected long duration (using preS-6P), in multiple experimental models https://www.pnas.org/doi/10.1073/pnas.2220403120

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 New CDC report for Covid hospitalization, age 65+, through August 2023.  A significant risk in older age groups; in this report only 24% of those hospitalized had received the booster (bivalent)
https://cdc.gov/mmwr/volumes/72/wr/mm7240a3.htm?s_cid=mm7240a3_w

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 On vaccines in today's Economist, worth a read https://www.economist.com/leaders/2023/10/05/in-an-ugly-world-vaccines-are-a-beautiful-gift-worth-honouring

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 The Novavax Covid booster was approved by FDA today 

 Had a scheduled appointment today a CCS pharmacy for a Covid vaccine booster. When I checked in, I’m told they ran out and they have “supply issues.” No prior notification, despite their having my email and text info.  Pathetic roll out and CVS execution 

 On Paxlovid rebound. 
In our prospective trial, it occurred in 14% vs 9% in controls, far less than anticipated, but more than Pfizer's trial https://nytimes.com/2023/09/26/well/live/covid-paxlovid-rebound.html?searchResultPosition=1

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 Propagation of misinformation for non-evidence based treatments for Covid
Results of a US survey of >13,000 people
Leading conduits: Trump, Fox News, Social media, Facebook
https://jamanetwork.com/journals/jama-health-forum/fullarticle/2809985

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 New findings that SARS-CoV-2 can directly infect and replicate in coronary arteries, promoting plaque inflammation atherosclerosis, and cardiovascular risk  https://nature.com/articles/s44161-023-00336-5 

 Vaccines, anti-vax, and political party; latest KFF poll
https://kff.org/coronavirus-covid-19/press-release/poll-nearly-half-of-adults-expect-to-get-the-new-covid-19-vaccine/?utm_campaign=KFF-2023-The-Latest&utm_medium=email&_hsmi=276068771&_hsenc=p2ANqtz-9l9Woih_9v4m5gBI2JuSQmHjml9NOv_HdQ9fxLtKjw_mSJ9PlMQE7PXPjsMeaxYzBlAeYathqOOzA6RDxLm60h9JQzKQ&utm_content=276068771&utm_source=hs_email

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 The most comprehensive lab assessment of #LongCovid including the immune system, cortisol, other viral pathogens (such as EBV), & proteins differentiates those affected (aligned w/ self-reported symptoms) with very high (96%) accuracy
https://nature.com/articles/s41586-023-06651-y

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 “A new type of vaccine… has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes—all without shutting down the rest of the immune system.”

Leveraging the liver!

https://erictopol.substack.com/p/an-exciting-new-approach-to-autoimmune

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 We've seen a cluster of advances in medical #AI in recent days, from randomized trials to making difficult diagnoses. The new Ground Truths gets into it all.

https://erictopol.substack.com/p/all-eyes-on-medical-ai

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 My new essay 
@ScienceMagazine
 on multimodal #AI in medicine
https://science.org/doi/full/10.1126/science.adk6139

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 Previously unpublished, presented at CDC meeting yesterday.  The prevalence of Long Covid by age in the US

https://media.mstdn.social/media_attachments/files/111/059/333/741/013/904/original/c359e23d350db85a.png 

 https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-09-12/07-COVID-Klein-508.pdf 

Important update on myocarditis from Covid mRNA vaccines for people age 12-39 who received bivalent boosters:
only 2 cases among over 550,000 people dosed

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 Here it is

https://media.mstdn.social/media_attachments/files/111/054/459/437/332/323/original/3f628c09a4815b93.png 

 The significance of the 1st human data for the new XBB.1.5 booster vs BA.2.86, 5 lab studies, a BA.2.86 outbreak in the UK, and all the latest #SARSCoV2 summarized in a new Ground Truths just posted https://erictopol.substack.com/p/the-ba286-variant-and-the-new-booster

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 The BA.2.86 variant nursing home outbreak in England
https://gov.uk/government/publications/investigation-of-sars-cov-2-variants-technical-briefings/sars-cov-2-variant-surveillance-and-assessment-technical-briefing-53
Hard to interpret. The spring booster was not XBB.1.5. The ventilation conditions are unknown. Good to see clinical and sequencing data. Highlights risk in older people. Keep 👀on this variant!

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 First human data for new XBB.1.5 booster vs the BA.2.86 variant: the neutralization antibody response looks very good, along with current main US circulating variants of EG.5.1 and FL.1.5.1
https://medrxiv.org/content/10.1101/2023.08.22.23293434v2
This adds to the 4 lab studies and is quite reassuring 👍

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