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"most important task" sounds horribly reductionist - as if we poor humans were mechanical utility maximizers, weighing out our options and choosing ultra-rationally among them.

That Peter Thiel thinks it's a good idea, is enough for me to want to behave in the opposite direction.

I am happy to report that most of the inbox that had been intimidating me has been cleared, and that a couple of necessary things were completed, and I'll take that as a victory for now. 
 @8eeabdf3 It's all about Agency: almost any practice sucks if imposed on your from above.
http://webseitz.fluxent.com/wiki/AgenCy
But giving yourself permission to focus on the most valuable thing in your infinite inbox, and let the rest slide, is not a bad deal.
http://webseitz.fluxent.com/wiki/SimplestThing