Wow, definitely. From the perspective of biology, our brain just creates an interpretation of the sensual inputs it gets, optimized for survival in the environment we live in. Reality is what we can see, hear, smell, touch, and measure with instruments. 
Is reality everything? Is it absolute? I don't think so. It is just a tiny fraction of 'what is'.
I ve always been wondering and asking myself how other lifeforms on this planet perceive reality, e.g. whales or ants, or trees. Will we ever be able to communicate with them? It might be mindblowing, confusing, and still mostly incomprehensible. 

Does reality only exist if we look? If there is no observer, the simulation might simply stop. All users logged out, game room closed  😆