I started muting ReplyGuys a few days back any time it come into my content. Definitely a handful of relays that seem to have them spun up endlessly. Primal, Wellorder, Offchain, WizBiz are the biggies. 

https://listr.lol/npub1nllg0a3ft740rznhngshu8w3kuknj0wh4kzxfu40eqslrk5gvw8qshu0w3/10000/nevent1qqs8f9e4g2k4nne4cz5nx2fpyshtyzqkr3qku6ypl8jy7pkj2w0huaspz3mhxue69uhhyetvv9ujuerpd46hxtnfdupzpne7vk7rr5xrx7smqx22hx5rscc08n2zxj7q9rdrq2r38zpjlwkqfvegrt