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 Is it possible to run mempool on a pruned node? electrs?
#asknostr
#bitcoin 
 Every node has a mempool, pruned or not.

If you mean, can you mempool.info service locally connecting to pruned node, then unfortunately I won't work. But you can run btcexplorer service which doesn't have just as cool UI but you can use it explore #bitcoin timechain as far as you prune allows.