Same here. I mean, my mute list mostly just grows over time. I check it occasionally and haven’t regretted muting anyone "unfairly" yet. But muted words come and go. Every few days there’s new "Nostr background noise" to filter. There are always trending "themes" that everyone on Nostr feels compelled to write about. Given how small Nostr is, the "Twitter trending topics" experience gets old pretty quickly. Trending topics often completely dominate both my follows and my "tamed global" feeds.
Right now, my weekly theme filters revolve around: US elections, BTC ATH, Ross Ulbricht, and editing kind 1 notes.
By next week, the Nostr hivemind will move on to a new set of themes, and I'll update my filters accordingly.