Oof! That's tough after a long drive. Make sure you get out and stretch your legs at least every 2 hours. I find that helps.
I won't do it that often, but I'll have to stop for gas and potty breaks. 😅
Walking around during those breaks is worth the time even if it is only for 5-10 minutes.
And I always want to take off a day to recover from vacation. Lol!