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 I think it's cruel for humans to breed a cat that doesn't have fur.  It's not in the best interest of the cat.  They need special care because they don't have fur (sunburn in summer and cold in the winter).  It's all so people don't have to deal with cat hair.  Well, hell. You have a cat.  You have to deal with some cat fur.  

Sphynx cats look like strange aliens to me. 
 @LuvGreenTea2019 I think a lot of the designer cat breeds are unethical because they're promoting mutations that can affect cats' health just because they look "interesting". Like flat faced cats, munchkins, and Scottish folds.