They are number 2. Number 1 is a drug called Humira, which is a "miracle drug" used for treating autoimmune diseases, especially rheumatoid arthritis. 

Look up the incidence rate of autoimmune disease on a historical chart btw. Everyone is bloody sick these days with one of these. 

 This is what I found
https://image.nostr.build/5341516f08c848557fac241b9360eb56c1d95b30bc7900b00ebe1a96d9c5c69e.jpg 

 Yup, that's pretty much accurate. 1-2% of ALL women now have Hashimoto disease. If our hunter gatherers were as sick as we are today, we would have gone extinct a long time ago.