After a brief early film career in Czechoslovakia, including the controversial Ecstasy (1933), she fled from her first husband, a wealthy Austrian ammunition manufacturer, and secretly moved to Paris. Traveling to London, she met Metro-Goldwyn-Mayer studio head Louis B. Mayer, who offered her a movie contract in Hollywood. She became a film star with her performance in Algiers (1938). 

 Her MGM films include Lady of the Tropics (1939), Boom Town (1940), H.M. Pulham, Esq. (1941), and White Cargo (1942). Her greatest success was as Delilah in Cecil B. DeMille's Bible-inspired Samson and Delilah (1949). She also acted on television before the release of her final film, The Female Animal (1958). She was honored with a star on the Hollywood Walk of Fame in 1960.