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 @59efb61a Not sure. Probably not, Id imagine. I agree it is luducrous and arbitrary. 

Take cocaine as the only vasoconstricting topical anesthetic effective in certain ENT procedures. 

Its still in use today. 
 @46cd5609 I also see what you said about dosing. For some meds it needs to vary depending on the day. I know plenty of docs who are down with that because it’s true. Days where less medicine is needed happen. Just one day of less medicine can maintain efficacy so the need to increase dose over time doesn’t happen. I know that. Do you think a lot of people who need these medicines also know this and self moderate, too?