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 I doubt if that will really work, since those transactions will be accepted by your node as valid once included in a block. 
 Yup. Free up some mempool but ultimately there is no change when considering the hard drive.  
 Yes of course, but as I said, if enough of us reject those tx in the mempool, they will be forced to find direct routes to miners, making their spamming more difficult. It's about sending a msg. 
 But what if I allow a small 80 bytes data carrier size? That is the default right? 
 I'm not sure that is enough, runes are very efficient in space, but yet can make fees to rise up because they compete on the position on the blockchain for a rune, which means to rise fees needlessly, affecting everybody else. 
 Runes use the exactly 80 bytes of data. (The OP_RETURN operator). If you put datacarriersize=0 in your conf file, any transaction that has OP_RETURN enabled will not be relayed by your node. So yes, if many nodes do it, it will be more difficult for the miners to learn about these transactions and to include them in blocks.