Can you make a guide to use Simplex with sane defaults over your own home server.

Somewhere I read if I run my home server via on on and that's the only server I am connected to there would be connectivity issues.

Is this (still) true?

And what's the best configuration I should point others to if they don't want or can run their own servers?

 

 If it's literally in your home, you have IP publicity issues, which you can solve with Tor Onion.  Also most residential homes change IPs, which Tor helps with.

If you're talking about a VPS, then I'd recommend the official script from the SimpleX website