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El Guiri | 5 months ago (raw) | root | parent | reply | flag +1 
 Out of curiosity, how does one even start to attack the problem of misfolded proteins? It seems like an incredibly complex problem
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heatherlarson | 5 months ago (raw) | root | parent | reply | flag 
 They have been trying for decades 🤣 they finally moved on and now there are clinical trials 🤷‍♀️
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nobody | 5 months ago (raw) | root | parent | reply | flag 
 just cook them, they denature
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reltbracco | 5 months ago (raw) | root | parent | reply | flag 
 They denature at temperatures way higher than cooking.
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nobody | 5 months ago (raw) | root | parent | reply | flag 
 and don't eat brains of your own species :)
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El Guiri | 5 months ago (raw) | root | parent | reply | flag +3 
 The BSE caused CJD was not canibalism remember. Feeding cows to cows and then eating them is potentially tantamount to the same thing but there’s a more dangerous potential for amyloidogenic proteins since 2021 which is why am curious
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heatherlarson | 5 months ago (raw) | root | parent | reply | flag +1 
 Yeah, me too. 

I had to give up that fight because I couldn’t win it. No one could. Look up how high in the court system creekstone went (and it lost). 

They silenced everyone. 

And this note cannot be deleted.
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El Guiri | 5 months ago (raw) | root | parent | reply | flag +1 
 Do you have a link?
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heatherlarson | 5 months ago (raw) | root | parent | reply | flag 
 This is everything we’ve got going for us right now: 

https://www.science.org/content/article/can-new-drugs-stop-deadly-set-brain-eating-diseases
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El Guiri | 5 months ago (raw) | root | parent | reply | flag +1 
 Thanks for the link. There’s one in there as well for the trial which is cool. I think I might pass this on to someone I follow who specialises in this area and see feedback. Considering they’re targeting mRNA in this trial and dna in others, it’s astonishing to see comment of 3-5 years for availability after a “successful trial”. Extremely cavalier. As a Brit and seeing some of the BSE mess (note it was probably worse in France but for some reason never made the headlines), I understand the desire for speed but considering the timing with current evidence slowly coming out that we have a potential new prion problem post 2021. It’s a little unnerving to see such a short follow up. Maybe am a little conservative and if only used in people suffering obvious disease, it’s a good thing. It’s a damned thought to diagnose early though
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heatherlarson | 5 months ago (raw) | root | parent | reply | flag 
 A clinical trial is supposed to take 10 years, not 3-5. 

But all involved sign up by choice… 🤷‍♀️ 

And if you’ve ever seen it, you would take the drug too. 

There is still no true clinical diagnosis if I’m not mistaken (other than autopsy). 

This is why us genetic folks are at the forefront of research. 

It’s usually not reported on much since it’s complicated. When it is, it’s usually the tired tropes of „one in a million” and that it is so-called „rare” 

The Science reporter did a superb job in reporting.