#Hormesis 
A Cold shock stress is a hormetic response that causes all kinds of genes that turn on/off to cycle on more frequently.  All kinds of positive things happen when you introduce hormetic stress.

Others besides cold shock include:
-Sauna (heat shock)
-Fasting
-Exercise 
-Fasting
-& eating some types of vegetables.  (Ie sulphur based like broccoli and garlic etc)
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