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 I’m not sure this solves the problem at all. Isn’t that just forcing clients to switch from relay to relay that doesn’t yet have spam?

Let’s use WoT and for whoever isn’t in it, you need some minimal PoW if you want your post seen… spammers will need to spend a lot of energy for their many posts but for a single user the energy will be minimal.

Don’t want to spend cpu cycles? zap the OP and your replies become visible. 🤷 
 Its more just to provide information so when they want to switch to manual mode with a small relay set they know what relays to use 
 wot is the best foot forward. it solves a lot of issues and gives the viewer an informed opinion. all clients should implement this. 
 👀 🌈 
 But 😀 many people believe 🎉 that's the best option. 
 CAさん=内閣府エージェント 🤔 
 Are there proof of work relays?

What is a reasonable pow number to have that is also annoying for spammers? 10?

I like the idea of pow posting as it means you won't miss new people or people way outside your bubble(s) 
 powrelay.xyz
labour.fiatjaf.com

every time you increase the required number of work bits by one, say from 9 -> 10, you effectively double the amount of work for a spammer.  
idk what would be a good requirement to set, but my goal would be to ensure replyguy would need to be running his script on a $50/mo server to keep going 😂 
 (Yeah I only said 10 cos you mentioned 10 lol)

I don't know how this would work tho. If I add these relays to will they automatically make it my notes are pow?  
 Nah, they require client support. Useless unless you build your own client. 
 sounds like you need to get Wired (.app) 
 if the spammers moved to GPUs it would negate a lot of that benefit, but it’s just another tool in the toolbox 
 I wish I could use those relays, but the popular Nostr clients don’t support PoW

We are stuck 
 zaps already support comments. Clients should show these comments accordingly as normal replies and allow replying. Then you could limit replies from people outside your WoT to those paying zaps, only.