#Tau pathology is a common denominator for #neurodegenerative diseases such as #Alzheimer’s disease or frontotemporal dementia, but selectively targeting toxic tau remains a challenge. Here, Gaikwad et al. developed a conformation-specific antibody for tau and demonstrated selective targeting of toxic tau aggregates in patient-derived tissue and tau oligomers in vitro. 

https://2medical.news/2024/08/02/nasal-tau-immunotherapy-clears-intracellular-tau-pathology-and-improves-cognitive-functions-in-aged-tauopathy-mice/