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 But IMO it is not worth it over Protonmail (or similar) even if possible. Better to live with the fact that E-Mail is not and will never be private.  
 and we don't have reliable nostr DMs yet either, which would be nice 
 The way I run it, email is private - but only when the other side has a similar setup, which is practically never :)

I like Protonmail too, it is a very good service.

Wish FreedomBox had an integrated mail server. 
 That's exactly the issue. The other side is (most likely) using gmail or similar and all email conversations get scanned. 

Practically nobody uses email e2ee. 

Just use signal/simplex for conversations.