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 @640e31bb we had reports of 20-200ms latency effects for incoming requests.

That was something they accepted may also be bad design of the services and this was a monolith making ~30-40 Postgres SQL calls per request.

Not sure if that's helps your request. Note that they were also using the agent in default mode (which I think is "all on") 
 @1c2c6506 Interesting. I don't suppose for a moment that they have a repro version of the app that they can open so we can have a proper dig about in it?

Tbh ~30-40 Pg calls / request sounds like it might be falling into the "Hibernate Cascade" antipattern.

There are always going to be workloads that are disturbed by the weaving that happens as a result of instrumentation. It's more a question of trying to identify how widespread (or pathological) they are.