Well, it does block anything that mentions mostr.pub. So, if you're using Amethyst that's an effective way of ridding your feed from mostr.pub content. I'm not sure if other clients have similar functionality.
nip05 domain-wide blocking with "hidden words" isn't working for me (Try to add `mostr.pub` to the hidden words and switch to Global - warning Mostr is pumping a lot of awful stuff across the bridge and isn't representative of most Fediverse content at all). Amethyst folks are already working on this. I'll try to build the PR later today. nostr:nevent1qqsd0zh0k43lkwxje8xde4efrwgdwvgt4tcw932wf8qartatgdrv3dsprdmhxue69uhksctkv4hzuctrvd5k7mre9eek7cmfv9kz7q3qa6we08n7zsv2na689whc9hykpq4q6sj3kaauk9c2dm8vj0adlajqxpqqqqqqzn8smax I'm still looking for an solution for noStrudel though.