Being locked down for almost three years affected me.  It affected my sister more.  My sister's 83 y/o friend was hit hard but the lock down.  She is a rule follower she she stayed inside.  I kept telling her to go outside and walk a bit and then use the stairs for exercise. Keep the legs strong. She didn't do this.

Brain power of over-50s dropped during Covid - study https://www.msn.com/en-us/health/other/brain-power-of-over-50s-dropped-during-covid-study/ar-AA1jf6eu 

 same 

 It all worked out VERY well and as engineered & intended for decades