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 所谓抗过敏药物,如果非要对比,左西替利嗪与地氯雷他定确实有可比性
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 所谓抗过敏药物,如果非要对比,左西替利嗪与地氯雷他定确实有可比性

1.结构与功能

西替利嗪包含两种旋光异构体,右旋体和左旋体

其中发挥抗过敏作用的主要为左旋体,而右旋体对中枢的不良反应较大

故提纯后的左西替利嗪,在保持药效的前提下,不良反应更小

地氯雷他定是氯雷他定被肝脏代谢后的产物

与氯雷他定相比,地氯雷他定的作用更强、药效持续时间更长、不良反应也较低

2.代谢

左西替利嗪主要通过肾脏排泄,受肝酶的影响很小,与其他药物发生相互作用的可能性也很小

地氯雷他定经肝脏代谢,目前未确定其代谢酶,尚未发现与其他药物的相互作用,但不能排除发生相互作用的可能性

左西替利嗪,适宜用于肝脏功能异常者,在用于肾功能中、重度不全时需要根据肾功能调整剂量

地氯雷他定,在用于肝功能异常时应减少剂量,严重肾功能不全慎用

3.不良反应

抗组胺药物典型的不良反应,是对中枢神经系统的影响

左西替利嗪的中枢神经系统不良反应较大,仍会产生一定的嗜睡、疲乏的不良反应

地氯雷他定,只有极少数人可能会出现困倦现象

所以用药期间需要驾驶汽车、操作机械者,更适宜选用地氯雷他定

左西替利嗪还可能增加尿潴留风险,有前列腺增生者应谨慎用药

两者都有可能引起癫痫发作或是加重,所以有癫痫和惊厥风险者,要谨慎用药 nostr.oxtr.dev 
 Sensor data: Temp 32.0°C, Humidity 77.1% 
 Sensor data: Temp 32.0°C, Humidity 77.1% nostr.oxtr.dev 
 For new nostriches that ask this question in your #introductions. The bad ass Kat has laid it all... 
 For new nostriches that ask this question in your #introductions. The bad ass Kat has laid it all out for you. nostr:note1pcf0kqmdn9mq634zwu6tk4snt08fjlgw78rvcdx89ssxmfyp0evs2qmzk5 nostr.oxtr.dev 
 Sunday on Fox at 8 PM eastern on Life, Liberty & Levin, Harris’s real hate-America agenda with two great guests: Charles Payne & Pete Hegseth! Set your DVR as well!  See you then! https://t.co/hLhebxnLCp https://video.twimg.com/ext_tw_video/1835125588803178496/pu/vid/avc1/1280x720/Fhej_IBy2V_rWx8B.mp4?tag=12 nostr.oxtr.dev 
 jews deserve extermination 
nostr:nevent1qqszgr8fy8dw8swgyw36l2wud4y2q47xz26p0hfx30y85ep70ve9n0cp... 
 jews deserve extermination 
nostr:nevent1qqszgr8fy8dw8swgyw36l2wud4y2q47xz26p0hfx30y85ep70ve9n0cpzamhxue69uhhyetvv9ujumn0wd68ytnzv9hxgtczyq49pslw9aqpmtf299km32e8flhtl783df0syu0cq824tptwpq5qkqcyqqqqqqguy4ks0 nostr.oxtr.dev 
 No in the muses. 
 No in the muses. nostr.oxtr.dev 
 MEGA HAPPENING!!! ... Proud boys storm Springfield Ohio. As we get closer and closer to the election, the violence will increase.   
Thread: https://boards.4chan.org/pol/thread/481691333

https://i.4cdn.org/pol/1726351031317984s.jpg nostr.oxtr.dev 
 **Astronomy Picture of the Day**

15 September 2024

**Find the Man in the Moon**

https://apod.nasa.gov/apod/image/2409/ManInMoon_Caxete_2770.jpg

Image Credit & Copyright: 
Dani Caxete


Have you ever seen the Man in the Moon? This common question plays on the ability of humans to see pareidolia -- imagining familiar icons where they don't actually exist. The textured surface of Earth's full Moon is home to numerous identifications of iconic objects, not only in modern western culture but in world folklore throughout history. Examples, typically dependent on the Moon's perceived orientation, include the Woman in the Moon and the Rabbit in the Moon. One facial outline commonly identified as the Man in the Moon starts by imagining the two dark circular areas -- lunar maria -- here just above the Moon's center, to be the eyes.  Surprisingly, there actually is a man in this Moon image -- a close look will reveal a real person -- with a telescope -- silhouetted against the Moon. This well-planned image was taken in 2016 in Cadalso de los Vidrios in Madrid, Spain.   Observe the Moon Night: NASA Coverage

#APOD #LunarMission #Astrodata #Astroengineering #LunarExploration

https://apod.nasa.gov/apod/ap240915.html
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