#Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? @M__Selvaraj @mpcontreras4 @KamounLab &co reveal that the helper NLR NRC2 flips from autoinhibited homodimer to active oligomeric resistosome upon activation #PLOSBiology https://plos.io/40e5fBU

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 Selective attention enables separation of overlapping speech in noisy environments. This study shows that #attention triggers bidirectional informational flow from #sensory regions to regions associated with semantic, syntactic & executive functions during active processing of #CocktailParty speech #PLOSBiology https://plos.io/3uZKBse

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 #ProteinQC pathways play key roles in resistance to #pathogens. @manishgrover_4 @barkoulab &co show that #proteasome regulation keeps #InnateImmune responses against natural pathogens of #Celegans in check in a tissue-specific manner #PLOSBiology https://plos.io/3PhIjLW

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 #Bacteria have a #DNAdamage response to aberrant #DNAmethylation, but how do they sense this damage? @Aditya_Kamat96 @Tung_BK_Le @dnarepairlab &co describe a TF that regulates a methylation-specific DNA damage response in #Caulobacter #PLOSBiology https://plos.io/3v7pdkD

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 Prospective #registration of animal studies could improve research transparency and reduce redundancy.

In this #PLOSBiology Perspective, @00591464 @461c2593 &co argue that registration should be integrated as part of animal #ethics review.

#research #science 

https://plos.io/3turO6U

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 Improved #ThreeParent conception for #MitochondrialDisease. A novel optimized strategy to perform spindle-chromosomal complex transfer (#SCCT) with minimal #mtDNA carryover and excellent #embryo development in both mouse & human models #PLOSBiology https://plos.io/3ZJIp2K

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 Open Peer Review is gaining prominence in attention and use, but more evidence is needed to responsibly open up #PeerReview.

@6fee7611 @5a4ecf81 & Serge Horbach propose a preliminary research agenda and issue a call-to-action.

#OpenScience #PLOSBiology

https://plos.io/46zUZEa

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 We are turning 20!🥳To celebrate, we're taking a closer look at #sciencepublishing.

In this Editorial, @717bc743, Hemai Parthasarathy & Emma Ganley, who have all previously been at the helm of #PLOSBiology, reflect on its beginnings and evolution as a journal.

https://plos.io/46kuClY

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 .@iris_unterweger &co map the dynamics of #liver development in #zebrafish, revealing how heterogeneous progenitor contributions in early #embryo shape the #CellType proportions of the tissue architecture and size of the adult organ. #PLOSBiology https://plos.io/3ZK64A9

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 .@tamram @GailPatricelli & @hebets_lab explore a new evolutionary model of mate choice copying, whereby young females mistakenly imprint on male traits not actually preferred by the female they copied. #PLOSBiology Paper: https://plos.io/46EHVgN Primer: https://plos.io/3RG28hX

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 Academic #journals have been publishing the results of biomedical research for more than 350 years. 

In this Essay, @768e77a0 examines how #sciencepublishing has changed in recent years and what its future might look like. 

#publishing #academia 

https://plos.io/3Q0kLfi

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 "I'll have what she's having!" Why do females choose particular mates? @EmilyHDuVal @servedio1 &co propose that mate choices rely on context-dependent social information, explaining major puzzles in the study of #SexualSelection, including why preferences vary among individuals and over time and how male trait variation is maintained. #PLOSBiology https://plos.io/46EHVgN

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 The proper distribution of resources between developmental programs and stress responses ensures survival and reproductive fitness. @SarahTorzone @RobDowenLab &co identify a #neurohormone pathway & two intestinal #MAPkinases that exert opposite effects on intestinal p38/PMK-1 signaling to maintain energy homeostasis in #Celegans. #PLOSBiology https://plos.io/3F0HcuA

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 Hybridizing #species are usually maintained by genome-wide selection against #introgression or by selection on a few “genomic islands.” @yanivbrandvain & Shelley Sianta explore #PLOSBiology study which finds a new pattern – 60 SNPs across the #genome differentiate #Penstemon species with different #pollinators. Paper: https://plos.io/3LGHkD9 Primer: https://plos.io/3RHSF9L

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 A study of #Penstemons with #bee & #hummingbird #pollination syndromes, by @carriewessi @LenaHileman &co, reveals ~20 "species-diagnostic loci" with fixed differences between syndromes, sprinkled throughout the genome in high-recomb regions #PLOSBiology https://plos.io/3LGHkD9

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 What does the future of #neuroscience look like in the age of big data and advanced #AI models? 

In this #PLOSBiology Perspective, @f06a9925 and Kevin Miller advocate for approaches that combine the merits of data-driven model discovery and hypothesis-driven model comparison.

https://plos.io/46rXI2o

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 Live-imaging of embryonic #skin reveals that #MesenchymalCells migrate rapidly & persistently for 3 hours after division, with the angle of #mitosis and direction & speed of migration controlled by tissue tension #PLOSBiology https://plos.io/48xlMCW

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 Spontaneous activity is an important attribute of neurodevelopment. @cssmity &co show that satellite #GlialCells in the #PNS display isolated spontaneous Ca2+ transients, sensitive to #mechanosensitive protein #Piezo1, revealing a role for #mechanobiology in the activity of developing neural cells #PLOSBiology https://plos.io/3t0Ko6w

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 To migrate efficiently, neutrophils must polarize their cytoskeletal regulators along a single axis of motion. @JasonPTown & @OWeinerLab use spatially-defined #optogenetic control of a leading edge organizer to explore how #neutrophil-like cells balance “decisiveness” (needed to polarize in one direction) with flexibility (to respond to new cues) #PLOSBiology https://plos.io/3ZAldnx

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 Brain #connectivity: physical links between regions, synchronized activity, or molecular similarities...? @JustineYHansen @misicbata &co integrate seven connectivity blueprints to characterize inter-regional relationships in the human #cortex. #PLOSBiology https://plos.io/3LBvQ3I

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 An animal’s capacity to thrive hinges on the nervous system translating environmental information into physiological responses. @ananya716 @scientistmomEB &co identify a post-transcriptional mechanism whereby ADAR #RNAbindingProteins regulate the key transcription factor PQM-1 in the #Celegans #NervousSystem to promote survival in low oxygen. #Hypoxia #RBPs #PLOSBiology https://plos.io/3Pxqs2X

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 Anaerobic #methanotrophic #archaea & sulfate-reducing #bacteria form a unique partnership in deep-sea ecosystems. @OrphanANME &co reveal a possible evolutionary trajectory of the bacterial partner towards this syntrophic lifestyle #PLOSBiology https://plos.io/46jNVuY

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 How do #CancerStemCells drive tumor growth & survival? @cg_hubert @SStaufferPhD @JustinLathia explore a #PLOSBiology #ColonCancer study revealing a pathway that links epigenetic regulation to self-renewal & therapeutic resistance Paper: https://plos.io/3ZliKgx Primer: https://plos.io/3RpjoYK

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 A novel TOX3-WDR5-H3K4me3/ABCG2 signaling axis is upregulated in #ColorectalCancer (CRC) #StemCells; these proteins may act as biomarkers for predicting CRC survival, and targets for countering drug tolerance, recurrence & #metastasis #PLOSBiology https://plos.io/3ZliKgx

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 Failure of #ProteinQC in #Celegans triggers a mechanism involving pathogen response factors & #lysosome-mediated degradation, promoting tissue-specific resilience to age-dependent #ProteinAggregation & #proteotoxicity @DellaDavid_Lab &co #PLOSBiology https://plos.io/44QeDdD

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 Non-linear #career trajectories are frequently punished in #academia. This #PLOSBiology Perspective shows why individuals might choose non-linear careers and how these benefit #diversity in #science.
https://plos.io/3LqMumG 

 #Aspergillus fumigatus, a saprotrophic #fungus that can cause serious life-threatening invasive infections, smashes the record for number of meiotic crossovers... ~30 per #chromosome (>2x the previous record holder) @TheRedBen @EvelineSnelders #PLOSBiology https://plos.io/3rc3k1L

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 We're hiring!!!! If you want to be part of a friendly team, reading fantastic science every day, think about joining @922cf958. Life science PhD essential, microbiology/immunology and/or editorial experience preferred. Full details here: https://plos.io/3rbSAjO 

 How does breast cancer recur after dormancy? @TTCooperPhD & @DrPostovit explore a #PLOSBiology study showing that #docetaxel-induced injury of #tumor stromal cells stimulates release of #cytokines that support dormancy escape of #BreastCancer cells. Paper: https://plos.io/3RjsGoQ Primer: https://plos.io/457Epuh

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 #Daylength guides the timing of biological processes in #plants. @Gendronlab use time course RNA-seq to thoroughly examine gene expression of #Arabidopsis in 3 photoperiods, uncovering previously unexplored photoperiodic gene regulation #PLOSBiology https://plos.io/46a5UEd

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 Study of #rice & #wheat shows that simply growing mixed plants from different genotypes can have stronger effects on #pathogen susceptibility than intrinsic susceptibility levels; implications for #NatureBasedSolutions for agriculture #PLOSBiology https://plos.io/3ZhRMX7

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 Chemotherapy awakens dormant #cancer. #Tumor stromal organoid & murine #BreastCancer model show that #chemotherapy injures stromal cells; this injury in turn invokes proinflammatory #cytokine signaling and can awaken dormant cancer cells #PLOSBiology https://plos.io/3RjsGoQ

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 #Bats are natural hosts for #viruses that cause higher case fatality rates in humans than do #zoonoses derived from any other source. @caraebrook @bootslab &co build a nested within-host, population-level model to explain this phenomenon #PLOSBiology https://plos.io/44Dri3y

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 Stressed? Sleep problems? #PLOSBiology Study reveals beneficial effects of #BrightLight treatment on stress-induced #sleep alterations; a visual circuit associated with the RMTg (rostromedial tegmental nucleus) underlies these effects https://plos.io/45HZlZQ

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 "A brick in the wall": reconstruction of a @PinkFloyd song from recorded neural activity, revealing involvement of the #SuperiorTemporalGyrus in information processing during #MusicPerception. Implications for #BrainComputerInterface #PLOSBiology https://plos.io/47zOgve

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