Relay devs and runners - do you limit massive filter subscriptions? Is it terrible to subscribe on a filter for kind 3 events for say 100,000 npubs?

Has anyone written a guide on relay filter etiquette? Or should I ask for what I need and if relays stop responding / block me, I submit smaller filters?

tagging a few folks that I know develop and run relays

#asknostr nostr:npub1utx00neqgqln72j22kej3ux7803c2k986henvvha4thuwfkper4s7r50e8 nostr:npub1l2vyh47mk2p0qlsku7hg0vn29faehy9hy34ygaclpn66ukqp3afqutajft nostr:npub18kzz4lkdtc5n729kvfunxuz287uvu9f64ywhjz43ra482t2y5sks0mx5sz