I've sometimes got 10 feeds going simultaneously and I need to know what to look at, first.

I turn off likes, usually.
I look at my favorite follows' replies first, then I look at zapper's stuff, then I turn off replies and look at boosts and quotes.

I only reply to all replies if it's a slow time, like Monday morning in Europe.

And now that we're moving the projects from Simplex and Slack to Nostr, and my gitstuff is high-prio, I'll need more filtering.

A reply to an issue should be top-level, for me.