To speak to your point nostr:nprofile1qqs8qy3p9qnnhhq847d7wujl5hztcr7pg6rxhmpc63pkphztcmxp3wgpzemhxue69uhkwun9v4h8xmm4dsh8xurpvdjj7qgswaehxw309ahx7um5wghx6mmd9uq35amnwvaz7tmwdaehgu3ww35x2umpd4jkxct59e5k7tckquc5r, its constraints everywhere. Just because the mouse dopamine button exists  doesn't mean that it is always right. 

Meaning is collective at all scales, its not just about the individual. Our microbiome influences our mood, signals us through cravings of what to eat to help our gut biota continue to persist -  biota that thrives on sugar will tell us to eat sugar but as a collective organism can choose against that and fix our diet, just as a society can put constraints on an individual who finds meaning from kicking puppies.