Hey! 
For 95% of the use cases, yes. 
No need to tinker with it. It will just sit and do its thing.

The first setting you might want to change is giving your lightning node an alias and a unique color 😊 

There are some settings that you might need to change down the road, but really all of this is due to specific functionalities you will learn with time. Of course feel free to go through the settings page, and read all the settings,  nostr:npub1aghreq2dpz3h3799hrawev5gf5zc2kt4ch9ykhp9utt0jd3gdu2qtlmhct does a great job explaining each toggle. 

Is there something specific you are noticing?