Practically speaking, not much. Maybe just the way they custody it.
Fiat is an unfair, rigged system which benefits the elites who can print money. People like Saylor are going to use that system to get as big of a Bitcoin position as possible. If anything, if I was Saylor or Blackrock, I'd say whatever stupid shit I needed to in order to shake people out and get cheaper Bitcoin. Everyone likes cheap Bitcoin and sellers provide the yield.