Heres how i got rid of reply guy in amythest (with screenshots)
Caveat emptor: this is a semi temporary fix because if he switches relays, I have to redo all this. It can become whackamole. But it's also easy and quick once you learn it.

1. Check any of reply guy's notes. See that little badge thing? Click it.
https://i.nostr.build/23f9E8azw4u6z1pr.jpg
2. This will give you a clue as to which relay reply guy is connected to. In this case it's 0xtr relay. Sorry nostr:npub1ktt8phjnkfmfrsxrgqpztdjuxk3x6psf80xyray0l3c7pyrln49qhkyhz0 i dont mean to put you on blast, they just happen to be spamming on your relay right now.
https://i.nostr.build/zV7PGwOwVx3NwUb1.jpg
3. Go to your relay list. (Click your pic top left and click relay) uncheck all the things to disconnect from the relay (or hit the red x to delete it outright). Don't forget to hit save.
Before 👇🏾
https://i.nostr.build/1hmBARgwicFuDL5a.jpg
After 👇🏾
https://i.nostr.build/VzFGkMaCesdOq2aC.jpg
4. Make sure to repeat these steps for every relay you found in step 1. In my case we only had one common relay. You might have more or different ones. Unless reply guy changes relays, all spam shld be gone. See! 👇🏾
https://i.nostr.build/HvHyIhkgaO3IGc9p.jpg
5. For good measure, I noted "test 2" then I turned the relay back on. Summoned reply guy, then turned it off again and posted goodbye. So far so good.
https://i.nostr.build/OPpm1E4cZw1dazQk.jpg
https://i.nostr.build/h6iImG4ZdrUgoqhc.jpg