Honestly, if you’re okay with the swing and you trust the underlying asset, you totally can. 
Firstly, Im a huge MSTR fan and irresponsibly over invested in it but it trades at ~2.4x bitcoin. 
A black swan event, would drop that multiple to well below 1:1 rather quickly. 
If you were holding MSTU during one of these events, we’re talking about a +90% drawdown.  
The fund would become insolvent and you’d lose it all.