https://www.nature.com/articles/s44271-024-00101-9?_gl=1*1hg5p9g*_up*MQ..*_gs*MQ..&gclid=Cj0KCQiAi_G5BhDXARIsAN5SX7reAakr-QE4NHFHOj8T0yZ_q1p2WE3Wdqh_yy9dmsLQbmbV8-AZV6MaAstUEALw_wcB