Yeah, there's different sorts, but a lot will have eg historical commentary, translation notes and variations, relevant notes from church fathers, even maps and whatnot. Depending on the version. But yes there would be certain things which would be better to ask a priest.

There's quite a good YouTube channel which goes super in-depth on bibles and study Bibles, what they contain. The good thing about OSB would be the inclusion of apocrypha, not sure which other versions would include that.

https://youtu.be/7BzYh3WskL4