#Vascular #cognitive impairment due to cerebral small #vessel disease is associated with cerebral pulsatility, white matter hypoperfusion, and reduced cerebrovascular reactivity (CVR), and is potentially improved by endothelium-targeted drugs such as cilostazol. Whether sildenafil, a phosphodiesterase-5 inhibitor, improves cerebrovascular dysfunction is unknown.


https://2medical.news/2024/06/17/cerebrovascular-effects-of-sildenafil-in-small-vessel-disease-the-oxharp-trial/