I have embodied a life of understanding reality only through the  lens of my own perceptions, and have also read Hoffman. I don't agree with the assertion that viewing the full breadth of reality is a path to extinction, as I don't believe it is possible to do so as humans. 

I like Hoffman's computer screen analogy, and that would be even less possible than a human "seeing" the flow of electricity through the circuits on a motherboard in a meaningful way, i.e. forming text and images displayed on a screen, but with no screen.

I believe I have consumed the right amount of psychedelics to be exposed to glimpses of altered realities, enough to understand there is much more out there than what we experience and perceive, but I feel no need to revisit that altered state.

I also maintain we have the concept of time all wrong. Cause and effect (in that order) are dubious and limited at best, and what we are beginning to understand through quantum mechanics will be transformative in our evolution as a species. The more I learn about the Hindu concepts of time, the more I sm finding them agreeable.