frogs are notable as being an animal with an extremely weak protective membrane against penetration of chemicals through their skin

in a metaphorical sense, one of the characteristics of people who are fond of the pepe meme are like frogs, they find it difficult to be happy while there is a constant flow of bullshit through their psychic skin

it affects everyone but the psychic frogs need more isolation and need to be in cleaner places to be healthy 

 Frogs have a much different symbology in alchemy