Jerks' daily job is to find targets, not sure if deindexing from aggregators would help much, you should then deindex from major public relays too, and only post your stuff on paid relays (paid to read, not only to write). Meaning, you shouldn't be on public Nostr if you're afraid to be found by someone determined to find you.

I think the only anti-harassment solution that could work on Nostr is client-side filtering, based on contact/mute lists, friends' reports, etc. Don't show replies from people you don't follow, or that were reported/muted many times by people you follow, or replies from public relays. I bet some of these policies are implemented an nos.social, but the issue is - everyone's using Damus/Amethyst/Primal, and those have nothing like that.

The way I see it, we should have a separate pluggable layer/API/NIP for content post-filtering, that can be plugged into any app: an app forms a feed (main/replies/notifs/anything) and then passes all the events from the feed to the filter, and filter returns various labels (spam/harassment/nsfw/impersonation/...), and app covers the content of the labeled event and shows labels above it. This way apps don't have to rebuild their feed building logic - just apply another layer above it, users would specify the filtering API endpoint in the settings and get the filtering they want. Safe mode could be 'cover notes from users I don't follow until filter returns it's labels - uncover if no bad labels returned', more reckless mode could be 'show notes first, only hide them if filter returns some bad labels'.  

If nos or anyone is interested in experimenting with me in this area, let me know.