After about 25 years longer than you with almost all the symptoms you mention, I came to realize that the base issue is inflammation and that it works like a chain reaction with feedback. Food, infection, etc can start inflammation anywhere then inflammatory agents spread everywhere increasing the likelihood that other areas enter the inflammatory state. The feedback occurs because the overall inflammatory state of the whole system increases the inflammation of the original trigger as well. Nasty stuff.
Its a self-perpetuating cycle, difficult to stop by eating better etc. 
After years of it I found the best way is to clamp down hard on it with antiinflammatories for a few days, then ease up slowly (for your kidneys' sake). Years ago I started with steroids and I was amazed how effective they were but long-term use was advised against. 
Recently I found etoricoxib (90mg/day until the inflammation levels reset - its very noticeable, then slow down until early symptoms appear again (mine are usually the joint pains). I'm down to 90mg every month on average to stop that chain reaction starting as needed.

Do you have gastric reflux too? I was surprised when the antiinflammatories helped there too.

Are you discussing this somewhere?
I'm thinking the toe tingling, numbness and calf cramps are real damage beyond the inflammatory cause - its not getting worse now, but other than that it doesn't seem to be improved by antiinflammatories
Specialists over 30 years or so have been quite useless in my case.